刘 扩
副研究员
邮箱:liukuo2015@sibcb.ac.cn
研究方向:
以小鼠为研究模型,开发并利用谱系示踪技术阐明机体在稳态或损伤修复中细胞命运可塑性及其分子调控机制。
教育经历:
(1)2015.09-2020.06,威斯尼斯人wns888入口中国分子细胞科学卓越创新中心(生物化学与细胞生物学研究所),博士
(2)2011.09-2015.06,河北农业大学,学士
科研经历:
(1)2020.07-2022.07,威斯尼斯人wns888入口中国生命与健康科学学院,博士后
(2)2022.07-2023.02,威斯尼斯人wns888入口中国生命与健康科学学院,助理研究员
(3)2023.03-至今 ,威斯尼斯人wns888入口中国生命与健康科学学院,副研究员
基金或人才项目:
(1)2023年国家自然科学基金面上项目(主持)
(2)2022年国科大杭高院自主立项科研项目(主持)
(3)2021年国家自然科学基金青年项目(主持)
(4)2021年杭州市高层次人才特殊支持计划培养类人才第一层次
(5)2020年中国博士后基金面上资助(主持,结题)
(6)2020年中国博士后基金站前特别资助(主持,结题)
以第一或共同第一作者发表论文:
(#共同第一作者, *共同通讯作者)
1. Liu K#,*, Jin H#, Zhang S, Tang M, Meng X, Li Y, Pu W, Lui KO, Zhou B*. Intercellular Genetic Tracing of Cardiac Endothelium in the Developing Heart. Developmental Cell, 2023, 10.1016/j.devcel.2023.05.021.
2. Liu K#, Tang M#, Xu W#, Meng X, Jin H, Han M, Pu J, Li Y, Jiao F, Sun R, Shen R, Lui KO, Lu L*, Zhou B*. An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo. Proc. Natl. Acad. Sci. U.S.A, 2023, 120:e2207210120.
3. Liu K#, Jin H#, Tang M, Zhang S, Tian X, Zhang M, Han X, Liu X, Tang J, Pu W, Li Y, He L, Yang Z, Lui KO and Zhou B*. Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing heart. Journal of Cell Biology, 2022, 221(6):e202108093.
4. Liu K, Tang M, Liu Q, Han X, Jin H, Zhu H, Li Y, He L, Ji H and Zhou B*. Bi-directional differentiation of single bronchioalveolar stem cells during lung repair. Cell Discovery, 2020, 6:1.
5. Liu K, Tang M, Jin H, Liu Q, He L, Zhu H, Liu X, Han X, Li Y, Zhang L, Tang J, Pu W, Lv Z, Wang H, Ji H and Zhou B*. Triple-cell lineage tracing by a dual reporter on a single allele. Journal of Biological Chemistry, 2020, 295(3): 690-700.(Cover story)
6. Liu K, Jin H and Zhou B*. Genetic lineage tracing with multiple DNA recombinases: A user's guide for conducting more precise cell fate mapping studies. Journal of Biological Chemistry, 2020, 295(19):6413-6424.
7. Liu K, Yu W, Tang M, Tang J, Liu X, Liu Q, Li Y, He L, Zhang L, Evans SM, Tian X*, Lui KO and Zhou B*. A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme. Development, 2018, 145(18): dev167775.
8. Jin H#, Liu K#, Huang X, Huo H, Mou J, Qiao Z*, He B* and Zhou B*. Genetic Lineage Tracing of Pericardial Cavity Macrophages in the Injured Heart. Circulation Research, 2022, 101161CIRCRESAHA122320567.(Cover story)
9. Jin H#, Liu K#, Tang J#, Huang X, Wang H, Zhang Q, Zhu H, Li Y, Pu W, Zhao H, He L, Li Y, Zhang S, Zhang Z, Zhao Y, Qin Y, Pflanz S, Kasmi KEI, Zhang W, Liu Z, Ginhoux F, Ji Y, He B, Wang L and Zhou B*. Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Nature Communications, 2021, 12(1): 2863.
10. Liu Q#, Liu K#, Cui G#, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H* and Zhou B*. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nature Genetics, 2019, 51(4):728-738.
11. Zhang H#*, Huang X#, Liu K#, Tang J#, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO and Zhou B*. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. Cell Research, 2017, 27(9): 1157-1177.
12. 刘扩, 唐暮雪,周斌*. 肺多潜能上皮干细胞在肺损伤修复中的作用. 生命的化学, 2019, 39 (2):211-216.