吴振芳
职称:副研究员
邮箱:zhenfwu@ucas.ac.cn
教育经历
(1)2009.9-2014.6,威斯尼斯人wns888入口中国微生物研究所,遗传学,博士学位
(2)2006.9-2009.7,四川农业大学,生物物理学,硕士学位
(3)2002.9-2006.7, 重庆邮电大学,生物信息学院,学士学位
科研经历
(1)2023.11-至今,威斯尼斯人wns888入口中国生命与健康学院,副研究员
(2)2019.1-2023.9,上海交通大学,医学院附属第九人民医院,副研究员
(2)2018.6-2019.1,上海交通大学,医学院附属第九人民医院,助理研究员
(3)2014.7-2018.5, 威斯尼斯人wns888入口中国,生物化学与细胞生物学研究所,博士后
研究方向
核内小体的结构和功能研究
基金及荣誉
1、2023年国家自然科学基金面上项目(主持)
2、2016年国家自然科学基金青年项目(主持)
3、中国博士后科学基金第57批面上资助(主持)
4、中国博士后科学基金第九批特别资助(主持)
5、2020年赛诺菲-威斯尼斯人wns888入口中国上海生命科学研究院优秀博士后奖励基金
6、威斯尼斯人wns888入口中国微生物研究所所长奖学金
7、博士研究生国家奖学金
代表性研究成果
第一作者/共同第一作者/共同通讯作者:
1、Sun H#, Wu Z#*, Zhou Y#, Lu Y, Lu H, Chen H, Shi S, Zeng Z*, Wu J*, Lei M* (2022) Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex. PLoS Genet 18: e1010308.
2、Wan F#, Ding Y#, Zhang Y#, Wu Z#, Li S, Yang L, Yan X, Lan P, Li G*, Wu J*, Lei M* (2021). Zipper head mechanism of telomere synthesis by human telomerase. Cell Res 31, 1275-1290.
3、Shi S#, Zhou Y#, Lu Y, Sun H, Xue J, Wu Z*, Lei M* (2021). Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres. Life Sci Alliance 4(11): e202101106.
4、Chen C#, Tan M#, Wu Z#, Zhang Y, He F, Lu Y, Li S, Cao M, Li G*, Wu J*, Cheng H*, Lei M* (2021). Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex. Sci Bull 66(23): 2347-2352.
5、Ge Y#, Wu Z#*, Chen H, Zhong Q, Li G, Wu J*, Lei M* (2020). Structural insights into telomere protection and homeostasis regulation by yeast CST complex, Nat Struct Mol Biol 27(8): 752-762.
6、Wu Z*, He MH, Zhang LL, Liu J, Zhang QD, Zhou JQ* (2018). Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae. DNA Repair (Amst) 72: 64~76.
7、Zhang LL, Wu Z*, Zhou JQ* (2018). Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae. J Genet Genomics 45(9): 467~476.
8、Wu Z, Liu J, Zhang QD, Lv DK, Wu NF, Zhou JQ* (2017) Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection. Nucleic Acids Res 45: 3308-3322.
9、Wu Z, Yang H, Liu J, Wang L, Xiang H* (2014) Association between dynamics of multiple replication origins and evolution of multireplicon genome architecture in haloarchaea. Genome Biol Evol 6: 2799-2810.
10、Wu Z, Liu J, Yang H, Liu H, Xiang H* (2014) Multiple replication origins with diverse controlling mechanisms in Haloarcula hispanica. Nucleic Acids Res 42, 2282-2294.
11、Wu Z, Liu J, Yang H, Xiang H* (2014) DNA replication origins in archaea. Front Microbiol 5: 179.
12、Wu Z, Liu H, Liu J, Liu X, Xiang H* (2012) Diversity and evolution of multiple orc/cdc6-adjacent replication origins in haloarchaea. BMC Genomics 13: 478.
参与作者:
1、Shao Y, Lu N, Wu Z, Cai C, Wang S, Zhang LL, Zhou F, Xiao S, Liu L, Zeng X, Zheng H, Yang C, Zhao Z, Zhao G*, Zhou JQ*, Xue X*, Qin Z* (2018). Creating a functional single-chromosome yeast. Nature 560(7718): 331-335.
2、Yang H, Wu Z, Liu J, Liu X, Wang L, Cai S, Xiang H* (2015) Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins. Nat Commun 6:8321.
3、Wang Q#, Li S#, Wan F#, Xu Y#, Wu Z, Cao M, Lan P*, Lei M*, Wu J* (2021). Structural insights into transcriptional regulation of human RNA polymerase III. Nat Struct Mol Biol 28 (2): 220-227.
4、Zhang C#, Shuai J#, Ran Z#, Zhao J, Wu Z, Liao R, Wu J*, Ma W*, and Lei M* (2020). Structural insights into NDH-1 mediated cyclic electron transfer. Nat Commun 11(1): 888.
5、He MH, Liu JC, Lu YS, Wu ZJ, Liu YY, Wu Z, Peng J, Zhou JQ* (2019). KEOPS complex promotes homologous recombination via DNA resection. Nucleic Acids Res 47(11):5684-5697.